Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance

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Ebert, Thomas
Anker, Stefan D.
Ruilope Urioste, Luis Miguel
Fioretto, Paola
Fonseca, Vivian

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Abstract

To explore whether insulin resistance, assessed by estimated glucose disposal rate (eGDR), is associated with cardiorenal risk and whether it modifies finerenone efficacy. Insulin resistance was associated with increased cardiovascular (but not kidney) risk and did not modify finerenone efficacy.

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Ebert, T., Anker, S. D., Ruilope, L. M., Fioretto, P., Fonseca, V., Umpierrez, G. E., Birkenfeld, A. L., Lawatscheck, R., Scott, C., Rohwedder, K., Rossing, P., & FIDELIO-DKD and FIGARO-DKD Investigators. (2024). Outcomes with finerenone in patients with chronic kidney disease and type 2 diabetes by baseline insulin resistance. Diabetes Care, 47(3), 362-370. https://doi.org/10.2337/dc23-1420

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