ABACUS Repository
Institutional repository of the Universidad Europea where the scientific production of its research community is collected. The purpose of the repository is to provide access and visibility to this work by gathering, preserving and disseminating this production.
Recent Submissions
A Sustained-Release Thermoplastic Polyurethane/Poly L-Lactide-Co-DL-Lactide (TPU/PLDLA) Cyclosporine-A Implant for the Treatment of Canine Keratoconjunctivitis Sicca: A Retrospective Case Series
(2026) Padjasek, Martyna; Cisło Sankowska, Anna; Pajuelo Gamez, David; Marycz, Krzysztof
To evaluate the efficacy of a Thermoplastic Polyurethane/Poly L- Lactide- Co- DL- Lactide (TPU/PLDLA) polymer blend containing cyclosporine (CsA) for the treatment of keratoconjunctivitis sicca (KCS) in dogs.
The TPU/PLDLA- CsA implant shows potential as an alternative to conventional topical CsA treatment for canine KCS, providing sustained release and reducing the need for frequent drug applications. The implant was generally well- tolerated, with observed improvements in tear production and inflammation reduction. Sedation was used for implantation, making the procedure less invasive compared to the general anesthesia required for some other implants. However, further studies with larger sample sizes and extended follow- up are required to confirm its long- term efficacy and safety, as well as to refine dosing and implantation protocols for optimal therapeutic outcomes.
Enhanced digestion and absorption kinetics of ultra–low molecular weight collagen containing di- and tripeptides: evidence from human and cell models
(2026) Nergiz Unal, Reyhan; Dierckx, Stephan; Roye, Chiara; Wu, Yingying; Maertens, Faye; Pajuelo Gamez, David; Merino, Marian; Mullor, José Luis; Depboylu, Bengu; Mandolesi, Carlos Daniel
Collagen hydrolysates differ in molecular weight distribution and composition, which may influence gastrointestinal absorption and epithelial transport.
Across both in vitro and in vivo models, ultra-low-molecular-weight collagen (LMWCP; 500 Da), with more than 45% di- and tripeptides, exhibited faster early-phase absorption kinetics, thereby enhancing early-phase bioavailability. Collagen-derived amino acids appeared across the epithelial layer within minutes and reached plasma peaks earlier, compared to a standard collagen hydrolysate.
These findings suggest that LMWCP exhibits distinct, accelerated absorption kinetics compared to conventional collagen hydrolysates.
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