ABACUS Repository

Institutional repository of the Universidad Europea where the scientific production of its research community is collected. The purpose of the repository is to provide access and visibility to this work by gathering, preserving and disseminating this production.

 

Recent Submissions

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Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial
(2026-04-13) Jacobs, Tom G.; Mumbiro, Vivian; Tembo, John; Egbe, Franklin N.; Moraleda, Cinta; dos Anjos Botas Beca, Laize Silvia; Passanduca, Alfeu; Kakooza, Lawrence; Domínguez Rodríguez, Sara
Cytomegalovirus (CMV) is a major unrecognised cause of morbidity and mortality in infants living with HIV. Valganciclovir, an oral prodrug of ganciclovir, treats CMV in immunocompromised patients, but pharmacokinetic data in infants living with HIV are lacking. This study evaluated exploratory valganciclovir pharmacokinetic and pharmacodynamic outcomes in infants with severe HIV-associated pneumonia.
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Interpretability as a leakage detector: a case study in machine-learning-based exoplanet detection with TESS
(2026) Rodríguez Rodríguez, Álvaro Manuel; Andrés Núñez, Eva María; Marín Díaz, Gabriel
The Transiting Exoplanet Survey Satellite (TESS) generates photometric time series for hundreds of thousands of stars, far more than can be vetted by hand, motivating machine-learning (ML) triage. We present a low-resource, interpretable pipeline that classifies TESS light curves as transit-bearing or not using a random forest trained on engineered summary features, treating feature-importance analysis as a formal auditing step, and apply it to Sector 68. The positive class comprises TESS-confirmed planet hosts; the negative class comprises Sector 68 targets with no catalogued planet or candidate, assembled from a different source.

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