ABACUS Repository

Institutional repository of the Universidad Europea where the scientific production of its research community is collected. The purpose of the repository is to provide access and visibility to this work by gathering, preserving and disseminating this production.

 

Recent Submissions

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Beyond maternal exercise: paternal exercise adaptations mediated by sperm microRNA signatures
(2026) Plaza Florido, Abel; Pérez Prieto, Inmaculada; Galvão, Daniel A.; Lucía Mulas, Alejandro
Preclinical and clinical evidence shows that maternal exercise can contribute to the cardiometabolic health of offspring. Recent tantalizing findings also point to several paternal factors, notably sperm microRNAs, that can mediate the intergenerational transmission of exercise benefits.
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Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors
(2026) Carrera Bastos, Pedro; Muskiet, Marcel H. A.; Mata Ordóñez, Fernando; Pruimboom, Leo; Lucía Mulas, Alejandro; Luque Huertas, Raúl Miguel; Muskiet, Frits A. J.
The “Warburg effect”, a metabolic adaptation observed in dividing cells, involves a shift from mitochondrial oxidative phosphorylation to cytoplasmic glucose metabolism. This metabolic process is characterized by increased cellular uptake of glucose and glutamine, elevated intracellular pH and sodium levels, enhanced protection against oxidative stress, altered autophagy, and increased lactate production. Initially identified by Otto Warburg in cancer cells, the Warburg effect is now recognized as a common feature of all dividing cells, prioritizing biomass production for cell proliferation over energy generation for specialized cellular functions. Through a comprehensive analysis of existing literature, we aim to shed light on the mechanisms underlying these interventions and their potential impact on disease progression and patient outcomes.

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