Wine polyphenols exert antineoplasic effect on androgen resistant PC-3 cell line through the inhibition of the transcriptional activity of COX-2 promoter mediated by NF-κβ
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Ferruelo, Antonio
Las Heras Alonso, Marta Mireya
Redondo, Cristina
Fata Chillón, Fernando Ramón de
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Abstract
Mediterranean diet may play a role in the prevention of prostate cancer (PCa) development and progression. Cyclooxygenase-2 (COX-2) expression is associated with increased cellular proliferation, prevents apoptosis and favors tumor invasion. We intend to clarify whether resveratrol and other polyphenols effectively inhibit COX-2 activity and induce apoptosis in hormone-resistant PC-3 cell line.
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Ferruelo, A., de Las Heras, M. M., Redondo, C., de Fata, F. R., Romero, I., & Angulo, J. C. (2014). Wine polyphenols exert antineoplasic effect on androgen resistant PC-3 cell line through the inhibition of the transcriptional activity of COX-2 promoter mediated by NF-κβ. Actas Urológicas Españolas (English Edition), 38(7), 429-437.