Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer’s Disease

Rubia Ortí, José Enrique de la; Sancho Castillo, Sandra; Benlloch, María; Julián Rochina, Mariano; Corchón Arreche, Silvia; García Pardo, María Pilar

doi:10.3233/JAD-160903

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Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer’s Disease

Rubia Ortí, José Enrique de la; Sancho Castillo, Sandra; Benlloch, María; Julián Rochina, Mariano; Corchón Arreche, Silvia; García Pardo, María Pilar

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/8756

Fecha: 2017

Materia UNESCO: Enfermedad del sistema nervioso
Materia UNESCO: Estrés mental
Materia UNESCO: Efectos fisiológicos

Tipo: article

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Resumen:

The understanding of how the immune system works, as well as its relationship with the stress level, seems to be important at the start of the Alzheimer’s disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA in patients with mild AD and healthy volunteers, and the production of both biomarkers was compared and correlated. In participants without AD, IgA was higher when cortisol was lower, and the opposite happened in participants with AD, with the quantification in saliva being a suitable method to determine it.

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