Reports regarding smoking differences in aklotho
expression have provided conflicting results. In the
current study we focused on the influence of smoking
intensity to serum levels of the aging molecule a-klotho in
healthy smokers. 40 middle aged healthy smokers without
airway obstruction or restriction were selected for the
analysis. Serum levels of soluble a-klotho were significantly
higher in heavy smokers (P\0.001). These results
are in agreement with the possibility that a-klotho acts as
anti-inflammatory molecule and strengthen the hypothesis
that an increase of serum levels of a-klotho might be a
compensatory response to smoking stress in healthy
population.