Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

Martín Alonso, M.; García Redondo, A. B.; Guo, D.; Camafeita, Emilio; Martínez, Fernando; Alfranca, A.; Méndez Barbero, N.; Pollán, Á.; Sánchez-Camacho Blázquez, Cristina; Denhardt, D. T.; Seiki, Motoharu; Vázquez, J.; Salaices, M.; Redondo, J. M.; Milewicz, D.; Arroyo, Alicia G.

doi:10.1161/CIRCRESAHA.117.305108

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Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

Martín Alonso, M.; García Redondo, A. B.; Guo, D.; Camafeita, Emilio; Martínez, Fernando; Alfranca, A.; Méndez Barbero, N.; Pollán, Á.; Sánchez-Camacho Blázquez, Cristina; Denhardt, D. T.; Seiki, Motoharu; Vázquez, J.; Salaices, M.; Redondo, J. M.; Milewicz, D.; Arroyo, Alicia G.

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/4565

Fecha: 2015

Materia UNESCO: Salud
Materia UNESCO: Sistema cardiovascular

Tipo: article

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Resumen:

Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as many as 75% of patients with a family history of aortic aneurysms do not have an identified genetic syndrome.

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