TY - JOUR A1 - Martín Alonso, M. AU - García Redondo, A. B. AU - Guo, D. AU - Camafeita, Emilio AU - Martínez, Fernando AU - Alfranca, A. AU - Méndez Barbero, N. AU - Pollán, Á. AU - Sánchez-Camacho Blázquez, Cristina AU - Denhardt, D. T. AU - Seiki, Motoharu AU - Vázquez, J. AU - Salaices, M. AU - Redondo, J. M. AU - Milewicz, D. AU - Arroyo, Alicia G. T1 - Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice Y1 - 2015 SN - 00097330 UR - http://hdl.handle.net/11268/4565 AB - Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as many as 75% of patients with a family history of aortic aneurysms do not have an identified genetic syndrome. KW - Cardiología KW - Salud KW - Sistema cardiovascular LA - eng ER -