The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Fuku, Noriyuki; Pareja Galeano, Helios; Zempo, Hirofumi; Alis, Rafael; Arai, Yasumichi; Lucía Mulas, Alejandro; Hirose, Nobuyoshi

doi:10.1111/acel.12389

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The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Fuku, Noriyuki; Pareja Galeano, Helios; Zempo, Hirofumi; Alis, Rafael; Arai, Yasumichi; Lucía Mulas, Alejandro; Hirose, Nobuyoshi

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/4414

Fecha: 2015

Materia UNESCO: Gen
Materia UNESCO: Genética humana
Materia UNESCO: Biología molecular
Materia UNESCO: Biología humana

Tipo: article

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Resumen:

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

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