The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

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dc.contributor.authorFuku, Noriyuki
dc.contributor.authorPareja Galeano, Helios
dc.contributor.authorZempo, Hirofumi
dc.contributor.authorAlis, Rafael
dc.contributor.authorArai, Yasumichi
dc.contributor.authorLucía Mulas, Alejandro
dc.contributor.authorHirose, Nobuyoshi
dc.date.accessioned2015-10-15T07:21:57Z
dc.date.available2015-10-15T07:21:57Z
dc.date.issued2015
dc.description.abstractMitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.spa
dc.description.filiationUEMspa
dc.description.impact5.760 JCR (2015) Q1, 36/187 Cell biology, 3/49 Geriatrics & gerontologyspa
dc.identifier.citationFuku, N., Pareja‐Galeano, H., Zempo, H., Alis, R., Arai, Y., Lucía, A., & Hirose, N. (2015). The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity?. Aging cell.spa
dc.identifier.doi10.1111/acel.12389
dc.identifier.issn14749718
dc.identifier.issn14749726
dc.identifier.urihttp://hdl.handle.net/11268/4414
dc.language.isoengspa
dc.peerreviewedSispa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsopen accessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherAgingspa
dc.subject.otherCentenariansspa
dc.subject.otherLongevity genespa
dc.subject.otherLongevity regulationspa
dc.subject.otherMitochondriaspa
dc.subject.otherMitochondrial DNAspa
dc.subject.otherMitochondrial DNA abnormalitiesspa
dc.subject.otherMolecular biology of agingspa
dc.subject.uemGenética humanaspa
dc.subject.uemBiologíaspa
dc.subject.unescoGenspa
dc.subject.unescoGenética humanaspa
dc.subject.unescoBiología molecularspa
dc.subject.unescoBiología humanaspa
dc.titleThe mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?spa
dc.typejournal articlespa
dspace.entity.typePublication
relation.isAuthorOfPublicationb96ef663-e66a-43f3-be8d-f182fa025510
relation.isAuthorOfPublicationd3691359-d7bd-4a12-b84e-338e28c81f9f
relation.isAuthorOfPublication.latestForDiscoveryb96ef663-e66a-43f3-be8d-f182fa025510

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