Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

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dc.contributor.authorTerreros Roncal, Julia
dc.contributor.authorMoreno Jiménez, Elena P.
dc.contributor.authorFlor García, Miguel
dc.contributor.authorRodríguez Moreno, Carla B.
dc.contributor.authorTrinchero, M. F.
dc.contributor.authorCafini Barrado, Fabio
dc.contributor.authorRábano, Alberto
dc.contributor.authorLlorens Martín, María
dc.date.accessioned2023-08-04T10:37:18Z
dc.date.available2023-08-04T10:37:18Z
dc.date.issued2021
dc.description.abstractDisrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult hippocampal neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dementia with Lewy bodies, and frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development and changes in the expression of differentiation markers. The ratio of quiescent to proliferating hippocampal neural stem cells shifted, and the homeostasis of the neurogenic niche was altered. Aging and neurodegenerative diseases reduced the phagocytic capacity of microglia, triggered astrogliosis, and altered the microvasculature of the dentate gyrus. Thus, enhanced vulnerability of AHN to neurodegeneration might underlie hippocampal dysfunction during physiological and pathological aging in humans.spa
dc.description.filiationUEMspa
dc.description.impact63.832 Q1 JCR 2021spa
dc.description.impact14.589 Q1 SJR 2021Spa
dc.description.impactNo data IDR 2021Spa
dc.description.sponsorshipSpanish Government (PID2020-113007RB-I00)spa
dc.description.sponsorshipSpanish Government (SAF-2017-82185-R)spa
dc.description.sponsorshipSpanish Government (RYC-2015-171899)spa
dc.description.sponsorshipAlzheimer's Association (2015-NIRG-340709)spa
dc.description.sponsorshipAlzheimer's Association (AARG-17-528125)spa
dc.description.sponsorshipAlzheimer's Association (AARG-17-528125-RAPID)spa
dc.description.sponsorshipAssociation for Frontotemporal Degeneration (2016 Basic Science Pilot Grant Award)spa
dc.description.sponsorshipCenter for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED, Spain)spa
dc.description.sponsorshipUniversidad Autonoma de Madrid (FPI-UAM 2017 program)spa
dc.description.sponsorshipFundacion Tatiana Perez de Guzmanspa
dc.description.sponsorshipSpain's Ministry for Economy and Competitiveness (PRE2018-085233)spa
dc.description.sponsorshipSpain's Ministry for Economy and Competitiveness (PEJ2018-001725-A)spa
dc.description.sponsorshipFundacion Ramon Arecesspa
dc.description.sponsorshipBanco de Santanderspa
dc.description.sponsorshipEuropean Research Council (ERC) Spanish Government (ERC-CoG-2020-101001916)spa
dc.identifier.citationTerreros-Roncal, J., Moreno-Jiménez, E. P., Flor-García, M., Rodríguez-Moreno, C. B., Trinchero, M. F., Cafini, F., Rábano, A., & Llorens-Martín, M. (2021). Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science, 374(6571), 1106–1113. https://doi.org/10.1126/science.abl5163spa
dc.identifier.doi10.1126/science.abl5163
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/11268/12253
dc.language.isoengspa
dc.peerreviewedSispa
dc.relation.publisherversionhttps://doi.org/10.1126/science.abl5163spa
dc.rights.accessRightsopen accessspa
dc.subject.otherTrastornos del Neurodesarrollospa
dc.subject.unescoNeurologíaspa
dc.subject.unescoCerebrospa
dc.subject.unescoEnfermedad del sistema nerviosospa
dc.titleImpact of neurodegenerative diseases on human adult hippocampal neurogenesisspa
dc.typejournal articlespa
dspace.entity.typePublication
relation.isAuthorOfPublicatione9c0e178-fcc3-4822-88b0-5042ccd5c89c
relation.isAuthorOfPublication.latestForDiscoverye9c0e178-fcc3-4822-88b0-5042ccd5c89c

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