A Paradox: α-Klotho Levels and Smoking Intensity
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Gonzalez-Moro, Jose Miguel
Chicharro García, Luis Miguel
Bandrés Moya, Fernando
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Abstract
Reports regarding smoking differences in aklotho
expression have provided conflicting results. In the
current study we focused on the influence of smoking
intensity to serum levels of the aging molecule a-klotho in
healthy smokers. 40 middle aged healthy smokers without
airway obstruction or restriction were selected for the
analysis. Serum levels of soluble a-klotho were significantly
higher in heavy smokers (P\0.001). These results
are in agreement with the possibility that a-klotho acts as
anti-inflammatory molecule and strengthen the hypothesis
that an increase of serum levels of a-klotho might be a
compensatory response to smoking stress in healthy
population.
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Verde, Z., González-Moro, J. M. R., Chicharro, L. M., Reinoso-Barbero, L., Bandrés, F., Gómez-Gallego, F., & Santiago, C. (2017). A Paradox: α-Klotho Levels and Smoking Intensity. Lung, 195(1), 53-57. DOI: 10.1007/s00408-016-9944-6