Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: The role of glucocorticoids
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Priego, Teresa
Ibáñez de Cáceres, Inmaculada
Martín Velasco, Ana Isabel
Villanúa, María de los Ángeles
López-Calderón, Asunción
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Abstract
The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP) - 3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.
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Priego, T., Ibáñez de Cáceres, I., Martín Velasco, A. I., Villanúa, M. A., & López-Calderón, A. (2002). Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: The role of glucocorticoids. Annals of the New York Academy of Sciences, 973, 88-90.