Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial

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dc.contributor.authorFiuza Luces, María del Carmen
dc.contributor.authorPadilla del Hierro, Julio Rubén
dc.contributor.authorValentín, Jaime
dc.contributor.authorSantana Sosa, Elena
dc.contributor.authorSantos-Lozano, Alejandro
dc.contributor.authorSanchís-Gomar, Fabián
dc.contributor.authorPareja Galeano, Helios
dc.contributor.authorMorales Rojas, Javier Salvador
dc.contributor.authorFleck, Steven J.
dc.contributor.authorPérez Ruiz, Margarita
dc.contributor.authorLassaletta, Álvaro
dc.contributor.authorSoares-Miranda, Luisa
dc.contributor.authorPérez Martínez, Antonio
dc.contributor.authorLucía Mulas, Alejandro
dc.date.accessioned2017-11-05T21:34:44Z
dc.date.available2017-11-05T21:34:44Z
dc.date.issued2017
dc.description.abstractThe purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive nature.spa
dc.description.filiationUEMspa
dc.description.impact1.843 JCR (2017) Q2, 25/65 Rehabilitation; Q3, 44/81 Sport Sciencesspa
dc.description.impact0.636 SJR (2017) Q2, 60/201 Physical Therapy, Sports Therapy and Rehabilitation, 39/125 Rehabilitation; Q3, 68/127 Sports Sciencespa
dc.description.impactNo data IDR 2017spa
dc.description.sponsorshipFondo de Investigaciones Sanitarias PI15/00558spa
dc.description.sponsorshipFondo de Investigaciones Sanitarias PI15/00558; Cátedra Real Madrid-Universidad Europea 2015/02RM, 2016/RM02; Conselleria de Educación, Investigación, Cultura y Deporte de la Generalitat Valenciana APOSTD/2016/140; Ministry of Education, Culture and Sport FPU14/03435; Sara Borrell ISCIII-MINECO-Spain/FEDER-EU CD14/00005spa
dc.identifier.citationFiuza-Luces, C., Padilla, J. R., Valentín, J., Santana-Sosa, E., Santos-Lozano, A., Sanchis-Gomar, F., ... & Lassaletta, A. (2017). Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial. American Journal of Physical Medicine & Rehabilitation, 96(11), 831-837.spa
dc.identifier.doi10.1097/PHM.0000000000000757
dc.identifier.issn0894-9115
dc.identifier.urihttp://hdl.handle.net/11268/6727
dc.language.isoengspa
dc.peerreviewedSispa
dc.rights.accessRightsrestricted accessspa
dc.subject.uemEducación físicaspa
dc.subject.uemCáncerspa
dc.subject.unescoEducación físicaspa
dc.subject.unescoCáncerspa
dc.titleEffects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trialspa
dc.typejournal articlespa
dspace.entity.typePublication
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