Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults

Abstract

Sedentary time has been associated with higher risk of cancer mortality, independent of physical activity (PA).1 However, questionnaire-based findings from a harmonized meta-analysis suggested that at least 50 to 65 minutes per day of self-reported moderate to vigorous PA eliminated the association between sedentary time and cancer mortality.2 Contrary to questionnaires that only capture blocks of PA (eg, 10–15 min of walking), wearable devices capture all movement and allow the differentiation of PA intensities, such as short bouts of vigorous intermittent lifestyle PA3,4 and light PA (LPA). To our knowledge, no wearable device-based study on the joint association of sedentary time and PA with cancer mortality exists.5 Understanding the amounts of movement at different intensities that attenuate the association between sedentary time and cancer mortality may help to inform future guidelines. We examined the joint association of sedentary time and intensity-specific PA with cancer mortality in UK adults.