Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice
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Martín Alonso, M.
García Redondo, A. B.
Guo, D.
Camafeita, Emilio
Martínez, Fernando
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Abstract
Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as many as 75% of patients with a family history of aortic aneurysms do not have an identified genetic syndrome.
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Martín-Alonso, M., García-Redondo, A. B., Guo, D., Camafeita, E., Martínez, F., Alfranca, A., ... & Arroyo, A. G. (2015). Deficiency of MMP17/MT4-MMP Proteolytic Activity Predisposes to Aortic Aneurysm in Mice. Circulation research, 117(2), e13-26.