Functional and Therapeutic Roles of Plant-Derived Antioxidants in Type 2 Diabetes Mellitus: Mechanisms, Challenges, and Considerations for Special Populations

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URI: https://hdl.handle.net/11268/17310
DOI: 10.3390/antiox14060725

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2025

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Martín Rodríguez, Alexandra
Beltrán Velasco, Ana Isabel
Rubio Zarapuz, Alejandro
Martínez Guardado, Ismael

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, oxidative stress, and inflammation, contributing to insulin resistance and long-term complications. Dietary antioxidants from plant sources, such as polyphenols, flavonoids, carotenoids, and phenolic acids, have been increasingly studied for their potential to modulate these pathophysiological mechanisms. This review aims to summarize and critically analyze the current evidence on the biological effects, therapeutic potential, and translational challenges of plant-derived antioxidants in the prevention and management of T2DM.

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Lucha contra las enfermedades
Investigación médica
Medicina preventiva

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Clemente-Suárez, V. J., Martín-Rodríguez, A., Beltrán-Velasco, A. I., Rubio-Zarapuz, A., Martínez-Guardado, I., Valcárcel-Martín, R., & Tornero-Aguilera, J. F. (2025). Functional and therapeutic roles of plant-derived antioxidants in type 2 diabetes mellitus: Mechanisms, challenges, and considerations for special populations. Antioxidants, 14(6), 725. https://doi.org/10.3390/antiox14060725
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https://doi.org/10.3390/antiox14060725

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journal article

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Área de Ciencias de la Salud
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