Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

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dc.contributor.authorSánchez-Menéndez, Clara
dc.contributor.authorRodríguez-Pérez, Jaime
dc.contributor.authorFuertes, Daniel
dc.contributor.authorLeguizamon, Valentina
dc.contributor.authorGonzález-Sanmartin, María
dc.contributor.authorMateos, Elena
dc.contributor.authorCervero, Miguel
dc.contributor.authorSan José Martínez, Esther
dc.contributor.authorSanz, Gonzalo
dc.contributor.authorÁlvaro, Edurne
dc.contributor.authorEt. al.
dc.date.accessioned2025-12-15T14:02:45Z
dc.date.available2025-12-15T14:02:45Z
dc.date.issued2025
dc.description.abstractThis study aims to discover novel immune biomarkers specific to EOCRC that may permit the development of a non-invasive, peripheral blood-based “liquid Immunoscore” that may integrate specific quantitative measurements. By contrasting the immune landscapes of EOCRC and LOCRC based on key immune cell subsets, exhaustion markers, soluble cytokines, and metabolic capacity, we seek to improve early detection, enable more timely and personalized treatment, and ultimately identify individuals under 50 at high risk for EOCRC before tumors become clinically detectable.
dc.description.filiationUEM
dc.description.impact5.9 Q1 JCR 2024spa
dc.description.impact1.941 Q1 SJR 2024spa
dc.description.impactNo data IDR 2024spa
dc.description.sponsorshipStrategic Action in Health of the Instituto de Salud Carlos III (ISCIII) (grant PI20/0974 and PI24/0729)
dc.description.sponsorshipPID2022-141317OB-I00
dc.description.sponsorshipCIBERINFEC (Centro de Investigación Biomédica en Red Enfermedades Infecciosas), group CB21/13/00015
dc.description.sponsorshipPIPF-2023_SAL-GL-30376
dc.description.sponsorshipISCIII-PFIS FI24/00326
dc.description.sponsorshipCIBERINFEC (CB21/13/00015).
dc.identifier.citationSánchez-Menéndez, C., Rodríguez-Pérez, J., Fuertes, D., Leguizamon, V., González-Sanmartín, M., Mateos, E., Cervero, M., San José, E., Sanz, G., Álvaro, E., Ballestero-Pérez, A., Martí-Gallostra, M., Rueda, J. A., Hurtado-Caballero, E., Pastor, C., Balaguer, F., Spinelli, A., Martínez-Laso, J., Torres, M., … Coiras, M. (2025). Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer. Frontiers in Immunology, 16, 1692382. https://doi.org/10.3389/fimmu.2025.1692382
dc.identifier.doi10.3389/fimmu.2025.1692382
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/11268/16617
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2025.1692382
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherNeoplasias colorrectales
dc.subject.otherDiagnóstico precoz
dc.subject.otherInmunidad
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCáncer
dc.subject.unescoMedicina preventiva
dc.subject.unescoInvestigación médica
dc.titleDifferences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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