Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer
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Sánchez-Menéndez, Clara
Rodríguez-Pérez, Jaime
Fuertes, Daniel
Leguizamon, Valentina
González-Sanmartin, María
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Abstract
This study aims to discover novel immune biomarkers specific to EOCRC that may permit the development of a non-invasive, peripheral blood-based “liquid Immunoscore” that may integrate specific quantitative measurements. By contrasting the immune landscapes of EOCRC and LOCRC based on key immune cell subsets, exhaustion markers, soluble cytokines, and metabolic capacity, we seek to improve early detection, enable more timely and personalized treatment, and ultimately identify individuals under 50 at high risk for EOCRC before tumors become clinically detectable.
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Sánchez-Menéndez, C., Rodríguez-Pérez, J., Fuertes, D., Leguizamon, V., González-Sanmartín, M., Mateos, E., Cervero, M., San José, E., Sanz, G., Álvaro, E., Ballestero-Pérez, A., Martí-Gallostra, M., Rueda, J. A., Hurtado-Caballero, E., Pastor, C., Balaguer, F., Spinelli, A., Martínez-Laso, J., Torres, M., … Coiras, M. (2025). Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer. Frontiers in Immunology, 16, 1692382. https://doi.org/10.3389/fimmu.2025.1692382
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https://doi.org/10.3389/fimmu.2025.1692382Type of document
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