Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank

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dc.contributor.authorAhmadi, Matthew
dc.contributor.authorMundell, Hamish
dc.contributor.authorSutherland, Greg
dc.contributor.authorHamer, Mark
dc.contributor.authorBlodgett, Joanna
dc.contributor.authorPozo Cruz, Borja del
dc.contributor.authorStamatakis, Emmanuel
dc.date.accessioned2025-12-17T19:47:43Z
dc.date.available2025-12-17T19:47:43Z
dc.date.issued2025
dc.description.abstractIt is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. The study examines the joint associations of intensity-specific physical activity and genetic predisposition (based on polygenetic risk score) with incident coronary heart disease (CHD), stroke, and atrial fibrillation (AF). This prospective cohort study included 303,950 adults (age = 56.4 ± 8.0 years, mean ± SD; 52.5% females) from the UK Biobank with physical activity and disease-related genotypes. Moderate-to-vigorous physical activity (MVPA) and intensity-specific activity was classified according to volume (e.g., MVPA was classified as none, low, medium, and high). Genetic predisposition for CHD, stroke, and AF were classified as low (Quintile 1), intermediate (Quintiles 2–4), and high (Quintile 5).
dc.description.filiationUEMspa
dc.description.impact10.3 Q1 JCR 2024spa
dc.description.impact3.197 Q1 SJRspa
dc.description.impactNo data IDR 2024spa
dc.description.sponsorshipSin financiación
dc.identifier.citationAhmadi, M. N., Mundell, H. D., Sutherland, G. T., Hamer, M., Sillanpää, E., Blodgett, J. M., Cruz, B. D. P., & Stamatakis, E. (2025). Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank. Journal of Sport and Health Science, 14, 101055. https://doi.org/10.1016/j.jshs.2025.101055
dc.identifier.doi10.1016/j.jshs.2025.101055
dc.identifier.issn2213-2961
dc.identifier.issn2095-2546
dc.identifier.urihttps://hdl.handle.net/11268/16628
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.jshs.2025.101055
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.otherEjercicio físico
dc.subject.otherPuntuación riesgo genético
dc.subject.otherEnfermedades cardiovasculares
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoEnfermedad cardiovascular
dc.subject.unescoInvestigación médica
dc.subject.unescoMedicina preventiva
dc.titlePhysical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication1aada854-e8ab-4b5d-a912-88254d445a17
relation.isAuthorOfPublication.latestForDiscovery1aada854-e8ab-4b5d-a912-88254d445a17

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