The role of mitochondrial derived peptides (MDPs) in metabolism
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Abstract
The term "mitokines" refers to signals derived from mitochondria that have an impact on other cells or tissues (Durieux et al., 2011). Rather than being simply a set of DNA composed by 37 genes, the mitochondrial DNA (mtDNA) is quite complex and includes small RNAs (Mercer et al., 2011). Mitochondrial-derived peptides (MDPs) are encoded by functional short open reading frames (sORFs) in the mtDNA.
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Alis, R., Lucia, A., Blesa, J. R., & Sanchis‐Gomar, F. (2015). The Role of Mitochondrial Derived Peptides (MDPs) in Metabolism. Journal of cellular physiology. [Epub ahead of print]