Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer

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dc.contributor.authorSimoes, Ana Rita
dc.contributor.authorCarlés González, Silvia
dc.contributor.authorLópez Doldan, María del Carmen
dc.contributor.authorDuran, Goretti
dc.contributor.authorFernández Montes, Ana
dc.contributor.authorFernández, María Perfecta
dc.contributor.authorSalgado Fernández, Mercedes
dc.contributor.authorGarcía Mata, Jesús
dc.contributor.authorPáez, David
dc.contributor.authorLópez Aspiroz, Elena
dc.contributor.authoret al.
dc.date.accessioned2025-10-10T13:28:59Z
dc.date.available2025-10-10T13:28:59Z
dc.date.issued2025
dc.description.abstractChemotherapeutic treatment for colorectal cancer (colorectal cancer) allows for increasedpatient overall survival. However, current therapeutic regimens are often associated with the development of adverse drug reactions, which represent amorbidity, mortality and economic issue. We propose to identify novel germ line markers that allow usto predict adverse drug reactions development after colorectal cancer chemotherapy. Overall, the present work has utilised state-of-the-art approaches to uncover several novel candidate toxicity variants/genes.
dc.description.filiationUEM
dc.description.impact7.7 Q1 JCR 2024
dc.description.impact2.344 Q1 SJR 2024
dc.description.impactNo data IDR 2023
dc.description.sponsorshipVer financiación en http://doi.org/10.1111/bph.70051
dc.identifier.citationSimoes, A. R., Carlés González, S., Lopez‐Doldan, M. D. C., Duran, G., Fernández‐Montes, A., Fernandez, M. P., Salgado Fernandez, M., Garcia Mata, J., Paez, D., Riera, P., Guino, E., Lopez‐Fernandez, L., Garcia De Santiago, B., López Aspiroz, E., Rojas, A., Castells, A., Castellvi‐Bel, S., Ruiz Ponte, C., Vymetalkova, V., … Fernandez‐Rozadilla, C. (2025). Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer. British Journal of Pharmacology, 182(21), 5340-5354. https://doi.org/10.1111/bph.70051
dc.identifier.doi10.1111/bph.70051
dc.identifier.issn0007-1188
dc.identifier.urihttps://hdl.handle.net/11268/16374
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttp://doi.org/10.1111/bph.70051
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherFarmacogenética
dc.subject.otherQuimioterapia
dc.subject.otherNeoplasias Colorrectales
dc.subject.sdgGoal 4: Quality education
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCiencias médicas
dc.subject.unescoGenética humana
dc.subject.unescoFarmacología
dc.titleNovel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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