Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer
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Simoes, Ana Rita
Carlés González, Silvia
López Doldan, María del Carmen
Duran, Goretti
Fernández Montes, Ana
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Abstract
Chemotherapeutic treatment for colorectal cancer (colorectal cancer) allows for increasedpatient overall survival. However, current therapeutic regimens are often associated with the development of adverse drug reactions, which represent amorbidity, mortality and economic issue. We propose to identify novel germ line markers that allow usto predict adverse drug reactions development after colorectal cancer chemotherapy.
Overall, the present work has utilised state-of-the-art approaches to uncover several novel candidate toxicity variants/genes.
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Simoes, A. R., Carlés González, S., Lopez‐Doldan, M. D. C., Duran, G., Fernández‐Montes, A., Fernandez, M. P., Salgado Fernandez, M., Garcia Mata, J., Paez, D., Riera, P., Guino, E., Lopez‐Fernandez, L., Garcia De Santiago, B., López Aspiroz, E., Rojas, A., Castells, A., Castellvi‐Bel, S., Ruiz Ponte, C., Vymetalkova, V., … Fernandez‐Rozadilla, C. (2025). Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer. British Journal of Pharmacology, 182(21), 5340-5354. https://doi.org/10.1111/bph.70051
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http://doi.org/10.1111/bph.70051Type of document
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