Proteomics signatures of human breast cancer: A systematic review
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García Chico, Celia
Plaza Florido, Abel
López Ortiz, Susana
Pinto Fraga, José
Maroto Izquierdo, Sergio
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Abstract
Proteomics can play an important role in advancing the discovery of cancer biomarkers. We aimed to synthesize current evidence concerning proteome signatures and molecular pathways involved in human breast cancer (BC).
Our review provides a comprehensive overview of the proteomic profile of patients with BC and may contribute to the understanding of the molecular changes associated with this disease. We highlighted hundreds of proteins, and various molecular pathways involved in BC, which could be considered potential biomarkers involved in the pathophysiology of the disease. Our results may also pave the way for new avenues to explore treatment targets.
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García-Chico, C., Plaza-Florido, A., López-Ortiz, S., Pinto-Fraga, J., Maroto-Izquierdo, S., Khoramipour, K., Sagarra-Romero, L., Fiuza-Luces, C., Lucia, A., & Santos-Lozano, A. (2025). Proteomics signatures of human breast cancer: A systematic review. Critical Reviews in Oncology/Hematology, 216, 104950. https://doi.org/10.1016/j.critrevonc.2025.104950