Regenerative Peripheral Nerve Interface (RPNI) and vascularized Denervated Muscle Targets (VDMT): a preclinical rabbit model as a translational feasibility and methodological platform

Abstract

Regenerative Peripheral Nerve Interfaces (RPNIs) and Vascularized Denervated Muscle Targets (VDMTs) are emerging strategies for nerve regeneration and myoelectric prosthesis control. Most preclinical studies have been conducted in rodents, limiting the evaluation of implantable electromyographic devices due to anatomical and scale-related constraints. This study aimed to develop and evaluate the first RPNI and VDMT models in rabbits as a translational platform for implantable neuromuscular interfaces.