ACE and ACTN3 genes and muscle phenotypes in nonagenarians

Thumbnail Image
Identifiers
URI: http://hdl.handle.net/11268/259
DOI: 10.1055/s-0030-1247529

Publication date

2010

Authors

Bustamante-Ara, Natalia

Advisors

Editors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics

Google Scholar

Research Projects

Organizational Units

Journal Issue

Abstract

We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i. e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n=41, 33 women, 8 men, age: 90-97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes ( ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.

Description

UNESCO Subjects

Genética humana

Keywords

Bibliographic reference

Bustamante-Ara, N., Santiago-Dorrego, C., Verde-Rello, Z., Yvert, T., Gómez-Gallego, F., Rodríguez-Romo, G., ..., & Lucía-Mulas, A. (2010). ACE and ACTN3 genes and muscle phenotypes in nonagenarians. International Journal of Sports Medicine, 31(4), 221-224.

Type of document

journal article

Collections

Área de Actividad Física y Salud