The applications of regenerative medicine in sinus lift procedures: A systematic review

Abstract

Background: Findings in regenerative medicine applied to the sinus lift procedures.

Purpose: Evaluate the effectiveness of regenerative medicine in sinus lift.

Materials and Methods: An extensive search for manuscripts were performed by using different combinations of keywords and MeSH terms (Pub‐med; Embase; Scopus; Web of Science Core Collection; Medline; Current Contents Connect; Derwent Innovations Index; Scielo Citation Index; Cochrane library). The full text selected articles are written in English, Portuguese, Spanish, Italian, German, or French, and published until 28 of November 2016. Inclusion criteria were: implant osteointegration, radiographic, histologic, and/or histomorphometric analysis, clinical studies in humans using of regenerative medicine. This systematic review was performed by selecting only randomized controlled clinical trials and controlled clinical trials.

Results: Eighteen published studies (11 CT and 7 RCT) were considered eligible for inclusion in the present systematic review. These studies demonstrated considerable variation of biomaterial and cell technics used, study design, sinus lift technic, outcomes, follow‐up, and results.

Conclusion: Only few studies have demonstrated potential of regenerative medicine in sinus lift; further randomized clinical trials are needed to achieve more accurate results.