First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia

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URI: http://hdl.handle.net/11268/12395
DOI: 10.1093/jpids/piad088

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2023

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Chabala, Chishala
Jacobs, Tom G.
Moraleda, Cinta
Ndaferankhande, John M.
Mumbiro, Vivian

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Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.

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Aparato respiratorio
Enfermedad transmisible
Pediatría

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Chabala, C., Jacobs, T. G., Moraleda, C., Ndaferankhande, J. M., Mumbiro, V., Passanduca, A., Namuziya, N., Nalwanga, D., Musiime, V., Ballesteros, A., Domínguez-Rodríguez, S., Chitsamatanga, M., Cassia, U., Nduna, B., Bramugy, J., Sacarlal, J., Madrid, L., Nathoo, K. J., Colbers, A., … Manukyan, L. (2023). First-line antituberculosis drug concentrations in infants with hiv and a history of recent admission with severe pneumonia. Journal of the Pediatric Infectious Diseases Society, 12(11), 581-585. https://doi.org/10.1093/jpids/piad088
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https://doi.org/10.1093/jpids/piad088

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journal article

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