Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells

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dc.contributor.authorRoger Laparra, Inés
dc.contributor.authorEstornut Navarro, Cristina
dc.contributor.authorMontero, Paula
dc.contributor.authorAparici, Mónica
dc.contributor.authorPuig, Carlos
dc.contributor.authorDavis, Andre M.
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorDiego, Alfredo de
dc.contributor.authorMilara, Javier
dc.contributor.authorCortijo, Julio
dc.date.accessioned2026-04-09T07:52:07Z
dc.date.available2026-04-09T07:52:07Z
dc.date.issued2026
dc.description.abstractChronic obstructive pulmonary disease (COPD) is characterized by sustained oxidative stress, inflammation, and epithelial damage. The transcription factor Nrf2 is a master regulator of antioxidant and cytoprotective defenses, and its dysregulation has been implicated in COPD pathogenesis.en
dc.description.filiationUEV
dc.description.impact4.7 Q1 JCR 2024
dc.description.impact1.197 Q1 SJR 2024
dc.description.impactNo data IDR 2024
dc.description.sponsorshipPID2020-114871RB-I00
dc.description.sponsorshipCIBERES (CB06/06/0027)
dc.description.sponsorshipInstituto de Salud Carlos III, PI20/01363
dc.description.sponsorshipPrometeo 2017/023/UV
dc.description.sponsorshipCIGE/2023/171
dc.identifier.citationRoger, I., Estornut, C., Montero, P., Aparici, M., Puig, C., Davis, A. M., Albericio, F., De Diego, A., Milara, J., & Cortijo, J. (2026). Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells. European Journal of Pharmacology, 1019, 178716. https://doi.org/10.1016/j.ejphar.2026.178716
dc.identifier.doi10.1016/j.ejphar.2026.178716
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.urihttps://hdl.handle.net/11268/17015
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.ejphar.2026.178716
dc.rights.accessRightsembargoed access
dc.subject.otherBiociencias
dc.subject.otherEnfermedad Pulmonar Obstructiva Crónica
dc.subject.otherActivación Neutrófila
dc.subject.otherSistema Inmunológico
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoInmunología
dc.subject.unescoAparato respiratorio
dc.subject.unescoInvestigación médica
dc.titleTargeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cellsen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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