Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells
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Roger Laparra, Inés
Estornut Navarro, Cristina
Montero, Paula
Aparici, Mónica
Puig, Carlos
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Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by sustained oxidative stress, inflammation, and epithelial damage. The transcription factor Nrf2 is a master regulator of antioxidant and cytoprotective defenses, and its dysregulation has been implicated in COPD pathogenesis.
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Roger, I., Estornut, C., Montero, P., Aparici, M., Puig, C., Davis, A. M., Albericio, F., De Diego, A., Milara, J., & Cortijo, J. (2026). Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells. European Journal of Pharmacology, 1019, 178716. https://doi.org/10.1016/j.ejphar.2026.178716