Therapeutic effect of cilastatin administration in LPS-induced retinotoxicity

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dc.contributor.authorSan Felipe Riba, Diego
dc.contributor.authorMartín Sanchez, Beatriz
dc.contributor.authorGonzález Nicolás, María
dc.contributor.authorLlorente Miguel, Ricardo
dc.contributor.authorMarco López, Eva María
dc.contributor.authorLópez Gallardo, Meritxell
dc.contributor.authorLázaro, Alberto
dc.date.accessioned2026-06-12T16:27:34Z
dc.date.available2026-06-12T16:27:34Z
dc.date.issued2026
dc.description.abstractSepsis is a life-threatening condition characterized by a dysregulated host response to infection that leads to multi-organ dysfunction. While its impact on the central nervous system is increasingly recognized, its effects on the retina require further study. Herein, this study aims to determine if systemic LPS‑induced sepsis causes retinal damage and whether cilastatin (CIL) may attenuate this injury.en
dc.description.filiationUEM
dc.description.impact7.5 Q1 JCR 2025
dc.description.impact2.074 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipInstituto de Salud Carlos III-Fondo de Investigación en Salud (PI20/01577)es
dc.description.sponsorshipISCIII-RICORS2040 (RD21/0005/0029)es
dc.description.sponsorshipRICORS2040-Renal (RD24/0004/0023)es
dc.description.sponsorship2022/BMD-7223es
dc.description.sponsorshipCPP2022–009633es
dc.identifier.citationSan Felipe, D., Martín-Sánchez, B., González-Nicolás, M. A., Llorente, R., Marco, E. M., López-Gallardo, M., & Lázaro, A. (2026). Therapeutic effect of cilastatin administration in LPS-induced retinotoxicity. Biomedicine & Pharmacotherapy, 200, 119557. https://doi.org/10.1016/j.biopha.2026.119557
dc.identifier.doi10.1016/j.biopha.2026.119557
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/11268/17159
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.biopha.2026.119557
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherBiociencias
dc.subject.otherLipopolisacáridos
dc.subject.otherCélulas ganglionares de la retina
dc.subject.otherEnfermedades neuroinflamatorias
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoEnfermedad del sistema nervioso
dc.subject.unescoInvestigación médica
dc.subject.unescoMedicina preventiva
dc.titleTherapeutic effect of cilastatin administration in LPS-induced retinotoxicity
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication

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