Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials

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dc.contributor.authorZeng, Haiyan
dc.contributor.authorSchagen, Sanne B.
dc.contributor.authorHendriks, Lizza E.L.
dc.contributor.authorSánchez Benavides, Gonzalo
dc.contributor.authorJaspers, Jaap P. M.
dc.contributor.authorManero, Rosa María
dc.contributor.authorLievens, Yolande
dc.contributor.authorMurcia Mejía, Mauricio
dc.contributor.authorKuenen, Marianne
dc.contributor.authorCouñago Lorenzo, Felipe
dc.contributor.authorEt. al.
dc.date.accessioned2025-09-25T14:31:04Z
dc.date.available2025-09-25T14:31:04Z
dc.date.issued2025
dc.description.abstractCognitive decline is an arising concern in patients who need cranial irradiation. We used the pooled longitudinal individual patient data of two phase III trials: NCT01780675 and PREMER to investigate whether hippocampal avoidance (HA)-PCI is associated with improved self-reported cognitive functioning (SRCF) compared with PCI without increasing brain metastases (BM) development within the HA area. Patients with stage I-IV small cell lung cancer (SCLC) were randomized to PCI or HA-PCI. SRCF was assessed and contrast enhanced brain magnetic resonance imaging (MRI) was performed at baseline and up to 24 months follow-up. SRCF and BM incidence after (HA)-PCI were compared between arms. Self reported cognitive impairment was defined as SCRF < 75.
dc.description.filiationUEMspa
dc.description.impact4.4 Q2 JCR 2024spa
dc.description.impact1.752 Q1 SJR 2024spa
dc.description.impactNo data IDR 2023spa
dc.description.sponsorshipScholarship of China Scholarship Council (Grant No.: CSC 201909370087)
dc.description.sponsorshipOtros patrocinadores en https://www.sciencedirect.com/science/article/abs/pii/S0169500224005701
dc.identifier.citationZeng, H., Schagen, S. B., Hendriks, L. E. L., Sánchez-Benavides, G., Jaspers, J. P. M., Manero, R. M., Lievens, Y., Murcia-Mejía, M., Kuenen, M., Rico-Oses, M., Albers, E. A. C., Samper, P., Houben, R., De Ruiter, M. B., Dieleman, E. M. T., López-Guerra, J. L., De Jaeger, K., Couñago, F., Lambrecht, M., … Rodríguez De Dios, N. (2025). Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials. Lung Cancer, 199, 108036. https://doi.org/10.1016/j.lungcan.2024.108036
dc.identifier.doi10.1016/j.lungcan.2024.108036
dc.identifier.issn1872-8332
dc.identifier.issn0169-5002
dc.identifier.urihttps://hdl.handle.net/11268/16212
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.lungcan.2024.108036
dc.rights.accessRightsembargoed access
dc.subject.otherCarcinoma Pulmonar de Células Pequeñas
dc.subject.otherMetástasis de la Neoplasia
dc.subject.otherProtocolo de Ensayo Clínico
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCáncer
dc.subject.unescoAparato respiratorio
dc.subject.unescoTratamiento médico
dc.titleImpact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublication2e374c15-a9f7-4137-99a8-6be419e2c462
relation.isAuthorOfPublication.latestForDiscovery2e374c15-a9f7-4137-99a8-6be419e2c462

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