Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials
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Zeng, Haiyan
Schagen, Sanne B.
Hendriks, Lizza E.L.
Sánchez Benavides, Gonzalo
Jaspers, Jaap P. M.
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Abstract
Cognitive decline is an arising concern in patients who need cranial irradiation. We used the pooled longitudinal individual patient data of two phase III trials: NCT01780675 and PREMER to investigate whether hippocampal avoidance (HA)-PCI is associated with improved self-reported cognitive functioning (SRCF) compared with PCI without increasing brain metastases (BM) development within the HA area.
Patients with stage I-IV small cell lung cancer (SCLC) were randomized to PCI or HA-PCI. SRCF was assessed and contrast enhanced brain magnetic resonance imaging (MRI) was performed at baseline and up to 24 months follow-up. SRCF and BM incidence after (HA)-PCI were compared between arms. Self reported cognitive impairment was defined as SCRF < 75.
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Zeng, H., Schagen, S. B., Hendriks, L. E. L., Sánchez-Benavides, G., Jaspers, J. P. M., Manero, R. M., Lievens, Y., Murcia-Mejía, M., Kuenen, M., Rico-Oses, M., Albers, E. A. C., Samper, P., Houben, R., De Ruiter, M. B., Dieleman, E. M. T., López-Guerra, J. L., De Jaeger, K., Couñago, F., Lambrecht, M., … Rodríguez De Dios, N. (2025). Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials. Lung Cancer, 199, 108036. https://doi.org/10.1016/j.lungcan.2024.108036