Acute toxicity of SBRT in localized prostate cancer: A Spanish multicenter study
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Romero Zoghbi, S. E.
López Campos, Fernando
Fernández Ibiza, Jaime
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Abstract
Stereotactic body radiation therapy (SBRT) has emerged as an effective option for the treatment of localized prostate cancer; however, data from real-world clinical practice remain limited. Between January 2020 and December 2023, 251 patients with localized prostate cancer treated with SBRT were included in 12 centers in Spain. The treatment volume included prostate ± seminal vesicles, without prophylactic pelvic radiotherapy. A dose of 35−40 Gy was prescribed in 5 fractions, every other day. Acute genitourinary (GU), gastrointestinal (GI) and sexual toxicity was assessed up to 6 months post-treatment using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. The aim purpose of this study is to evaluate the safeness of the Five-fraction SBRT treatment.
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Romero Zoghbi, S. E., López Campos, F., Sanz-Rosa, D., Fernández Ibiza, J., Thuissard-Vasallo, I. J., Andreu-Vázquez, C., Laria, C., Andreescu Yagüe, J., Krumina, E., Ocanto, A., Mateos, M., Glaría, L. A., García Cuesta, J. A., Gonsalves, D., Fernández, C., Esteban, D., Begara De La Fuente, J., Rivas, D., López Ramírez, E., … Couñago, F. (2025). Acute toxicity of SBRT in localized prostate cancer: A Spanish multicenter study. Actas Urológicas Españolas (English Edition), 49(8), 501798. https://doi.org/10.1016/j.acuroe.2025.501798