Paclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patients

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dc.contributor.authorMontero Magalló, Paula
dc.contributor.authorPérez Leal, Martín
dc.contributor.authorPérez Fidalgo, J. A.
dc.contributor.authorSanz, Celia
dc.contributor.authorEstornut Navarro, Cristina
dc.contributor.authorRoger Laparra, Inés
dc.contributor.authorMilara, Javier
dc.contributor.authorCervantes, Andrés
dc.contributor.authorCortijo, Julio
dc.date.accessioned2022-03-03T14:54:07Z
dc.date.available2022-03-03T14:54:07Z
dc.date.issued2022
dc.description.abstractSkin toxicity is one of paclitaxel’s adverse effects. However, its real impact on the skin could be underestimated as these alterations can also appear asymptomatic. We have observed that paclitaxel modifies gene and protein expression of skin markers in a 3D epidermis model, and impairs physical, physiological, and biomechanical properties of the skin in gynecologic cancer patients. These subclinical alterations might be avoided by using prophylactic measures during treatment to prevent possible future adverse reactions.spa
dc.description.filiationUEVspa
dc.description.impact5.2 Q2 JCR 2022spa
dc.description.impact1.312 Q1 SJR 2022spa
dc.description.impactNo data IDR 2022spa
dc.description.sponsorshipFondo Europeo de Desarrollo Regional (FEDER)spa
dc.description.sponsorshipInstituto de Salud Carlos III (PI20/01363)spa
dc.description.sponsorshipGobierno de España, CIBERES (CB06/06/0027)spa
dc.description.sponsorshipGeneralitat Valenciana, Prometeo (2017/023/UV)spa
dc.identifier.citationMontero, P., Pérez-Leal, M., Pérez-Fidalgo, J. A., Sanz, C., Estornut, C., Roger, I., Milara, J., Cervantes, A., & Cortijo, J. (2022). Paclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patients. Cancers, 14(5), 1146. https://doi.org/10.3390/cancers14051146spa
dc.identifier.doi10.3390/cancers14051146
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11268/10881
dc.language.isoengspa
dc.peerreviewedSispa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen accessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherOncologíaspa
dc.subject.otherDermatologiaspa
dc.subject.otherGinecologíaspa
dc.subject.otherQuimioterapiaspa
dc.subject.unescoFarmacologíaspa
dc.subject.unescoCáncerspa
dc.subject.unescoEnfermedad de la pielspa
dc.subject.unescoSalud de la mujerspa
dc.titlePaclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patientsspa
dc.typejournal articlespa
dspace.entity.typePublication

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