Predictors of HIV reservoir size and decay dynamics in early-treated paediatric infection: a prospective, multicentre longitudinal cohort study

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dc.contributor.authorReddy, Kavidha
dc.contributor.authorDomínguez Rodríguez, Sara
dc.contributor.authorMolechan, Chantal
dc.contributor.authorCotton, Mark
dc.contributor.authorOtwombe, Kennedy
dc.contributor.authorLain, Maria Grazia
dc.contributor.authorNhampossa, Tacilta
dc.contributor.authorMaiga, Almoustapha Issiaka
dc.contributor.authorBarnabas, Shaun
dc.contributor.authorTagarro García, Alfredo
dc.contributor.authorEt. al.
dc.date.accessioned2026-10-27T11:10:59Z
dc.date.available2026-10-27T11:10:59Z
dc.date.issued2026
dc.description.abstractEarly antiretroviral therapy after perinatal HIV infection can restrict reservoir size and diversity, offering potential for remission. This study evaluates HIV-1 DNA dynamics up to four years of age and predictors of reservoir size in early-treated African children through a prospective, multicentre cohort study about infants with perinatal HIV from South Africa, Mozambique, and Mali.en
dc.description.filiationUEMspa
dc.description.impact11.2 Q1 JCR 2025
dc.description.impact3.742 Q1 SJR 2025
dc.description.impactNo data IDR 2025
dc.description.sponsorshipEPIICAL consortium through ViiV Healthcare and Penta Foundationen
dc.identifier.citationReddy, K., Domínguez-Rodríguez, S., Molechan, C., Cotton, M., Otwombe, K., Lain, M. G., Nhampossa, T., Maiga, A. I., Barnabas, S., Vaz, P., Violari, A., Fernández-Luis, S., Behuhuma, N. O., Sylla, M., Liberty, A., Smit, T., Ording-Jespersen, G., Ismael, N., Giaquinto, C., … Estevao, L. (2026). Predictors of HIV reservoir size and decay dynamics in early-treated paediatric infection: A prospective, multicentre longitudinal cohort study. eBioMedicine, 133, 106510. https://doi.org/10.1016/j.ebiom.2026.106510
dc.identifier.doi10.1016/j.ebiom.2026.106510
dc.identifier.issn2352-3964
dc.identifier.urihttps://hdl.handle.net/11268/17514
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/j.ebiom.2026.106510
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.otherBiociencias
dc.subject.otherTerapia antirretroviral altamente activa
dc.subject.otherInfecciones por VIH
dc.subject.otherAtención perinatal
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoSida
dc.subject.unescoPediatría
dc.subject.unescoMedicina preventiva
dc.titlePredictors of HIV reservoir size and decay dynamics in early-treated paediatric infection: a prospective, multicentre longitudinal cohort study
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationf0bf0892-c73b-4af1-bbfe-edcb3e5c17b2
relation.isAuthorOfPublication.latestForDiscoveryf0bf0892-c73b-4af1-bbfe-edcb3e5c17b2

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