Predictors of HIV reservoir size and decay dynamics in early-treated paediatric infection: a prospective, multicentre longitudinal cohort study
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Reddy, Kavidha
Domínguez Rodríguez, Sara
Molechan, Chantal
Cotton, Mark
Otwombe, Kennedy
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Abstract
Early antiretroviral therapy after perinatal HIV infection can restrict reservoir size and diversity, offering potential for remission. This study evaluates HIV-1 DNA dynamics up to four years of age and predictors of reservoir size in early-treated African children through a prospective, multicentre cohort study about infants with perinatal HIV from South Africa, Mozambique, and Mali.
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Reddy, K., Domínguez-Rodríguez, S., Molechan, C., Cotton, M., Otwombe, K., Lain, M. G., Nhampossa, T., Maiga, A. I., Barnabas, S., Vaz, P., Violari, A., Fernández-Luis, S., Behuhuma, N. O., Sylla, M., Liberty, A., Smit, T., Ording-Jespersen, G., Ismael, N., Giaquinto, C., … Estevao, L. (2026). Predictors of HIV reservoir size and decay dynamics in early-treated paediatric infection: A prospective, multicentre longitudinal cohort study. eBioMedicine, 133, 106510. https://doi.org/10.1016/j.ebiom.2026.106510
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https://doi.org/10.1016/j.ebiom.2026.106510Type of document
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