Tumour SNPs Associated with Immune-Related Hepatitis in Patients with Melanoma Receiving Immune Checkpoint Inhibitors

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dc.contributor.authorRodríguez Piñas, José María
dc.contributor.authorRomero Lorca, Alicia
dc.contributor.authorGaibar Alonso, María
dc.contributor.authorNovillo Villajos, Apolonia
dc.contributor.authorRubio Alonso, Margarita
dc.contributor.authorMalón, Diego
dc.contributor.authorAntón Pascual, Beatriz
dc.contributor.authorCamacho Castañeda, Francisca Inmaculada
dc.contributor.authorCavanagh, Mercedes
dc.contributor.authorFernández Santander, Ana
dc.contributor.authorEt. al.
dc.date.accessioned2026-06-10T08:18:36Z
dc.date.available2026-06-10T08:18:36Z
dc.date.issued2025
dc.description.abstractImmune checkpoint inhibitors (ICIs) have significantly improved survival rates for patients with metastatic melanoma. However, these treatments can lead to immune-related adverse events (irAEs), including hepatitis. This exploratory study sought to identify tumour single-nucleotide polymorphisms (SNPs) associated with the risk of ICI-induced hepatitis in melanoma patients.en
dc.description.filiationUEMspa
dc.description.impact3.9 Q2 JCR 2024
dc.description.impact1.165 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipGrant 2022/UEM19
dc.identifier.citationRodríguez-Piñas, J. M., Romero-Lorca, A., Gaibar, M., Novillo, A., Rubio, M., Malón, D., Antón-Pascual, B., Camacho, F. I., Cavanagh, M., Luján, D. R., Martín, A. M., Khedaoui, R., Moreno, D., Pinedo, F., Boiza, M., García-Adrián, S., Gómez, P., Marrupe, D., & Fernández-Santander, A. (2025). Tumour snps associated with immune-related hepatitis in patients with melanoma receiving immune checkpoint inhibitors. Biomedicines, 13(10), 2351. https://doi.org/10.3390/biomedicines13102351
dc.identifier.doi10.3390/biomedicines13102351
dc.identifier.issn2227-9059
dc.identifier.urihttps://hdl.handle.net/11268/17154
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.3390/biomedicines13102351
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.otherMedicina
dc.subject.otherMelanoma
dc.subject.otherBiomarcadores
dc.subject.otherHepatitis
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.unescoCáncer
dc.subject.unescoPatología
dc.subject.unescoInmunología
dc.titleTumour SNPs Associated with Immune-Related Hepatitis in Patients with Melanoma Receiving Immune Checkpoint Inhibitorsen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery6df66eed-0c97-49a7-87e4-7052fb851239

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