Tumor Signatures of Physical Fitness: Insights from a Preclinical Model

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dc.contributor.authorSantos Lozano, Alejandro
dc.contributor.authorPlaza Florido, Abel
dc.contributor.authorCarrera Bastos, Pedro
dc.contributor.authorPérez Prieto, Inmaculada
dc.contributor.authorHernández Belmonte, Alejandro
dc.contributor.authorKamalinejad, Fatemeh
dc.contributor.authorGonzález Gálvez, Beatriz
dc.contributor.authorLópez, Juan A.
dc.contributor.authorFleck, Steven J.
dc.contributor.authorLucía Mulas, Alejandro
dc.contributor.authoret al.
dc.date.accessioned2026-07-16T17:15:08Z
dc.date.available2026-07-16T17:15:08Z
dc.date.issued2026
dc.description.abstractCardiorespiratory fitness (CRF) and muscle strength are associated with cancer risk/ mortality in adults. However, there is yet no evidence for pediatric tumors. This study investigated the association of CRF and muscle strength with several tumor-related phenotypes in an aggressive childhood malignancy, high-risk neuroblastoma (HR-NB). Besides the association of CRF with clinical severity of the tumor, distinct novel tumor proteomic signatures associated with CRF and muscle strength were identified, highlighting potential mechanisms linking physical fitness with childhood cancer biology.en
dc.description.filiationUEMspa
dc.description.impact4.0 Q1 JCR 2025
dc.description.impact1.481 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipFinanciado por Wereld Kanker Onderzoek Fonds (WKOF), como parte del programa World Cancer Research Fund International (grant # IIG_FULL_2021_007).es
dc.description.sponsorshipFinanciado por el Ministerio de Ciencia e Innovación de España (Fondo de Investigaciones Sanitarias [FIS]), cofinanciado por la Unión Europea.es
dc.description.sponsorshipFinanciado por el Instituto de Salud Carlos III (ISCIII) con el proyecto de investigación PI20/00147, cofinanciado por la Unión Europea.es
dc.description.sponsorshipVer financiación en https://doi.org/10.1249/MSS.0000000000003836es
dc.identifier.citationSantos-Lozano, A., Plaza-Florido, A., Carrera-Bastos, P., Pérez-Prieto, I., Hernández-Belmonte, A., Kamalinejad, F., Gálvez, B. G., López, J. A., Lumbreras, J., Rincón-Castanedo, C., Martín-Ruiz, A., Fleck, S. J., López-Soto, A., Yanguas-Casás, N., Pinós, T., Lucia, A., & Fiuza-Luces, C. (2026). Tumor signatures of physical fitness: Insights from a preclinical model. Medicine & Science in Sports & Exercise, 58(1), 35-46. https://doi.org/10.1249/MSS.0000000000003836
dc.identifier.doi10.1249/MSS.0000000000003836
dc.identifier.issn0195-9131
dc.identifier.issn1530-0315
dc.identifier.urihttps://hdl.handle.net/11268/17279
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1249/MSS.0000000000003836
dc.rights.accessRightsembargoed access
dc.subject.otherCiencias del Deporte
dc.subject.otherNeuroblastoma
dc.subject.otherAptitud Física
dc.subject.otherFuerza Muscular
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.sdgGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation
dc.subject.sdgGoal 4: Quality education
dc.subject.unescoCiencias médicas
dc.subject.unescoCáncer
dc.subject.unescoBiología molecular
dc.titleTumor Signatures of Physical Fitness: Insights from a Preclinical Modelen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationfb105818-15df-49c5-9ec1-a5d09b4aa278
relation.isAuthorOfPublicationd3691359-d7bd-4a12-b84e-338e28c81f9f
relation.isAuthorOfPublication.latestForDiscoveryfb105818-15df-49c5-9ec1-a5d09b4aa278

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