Tumor Signatures of Physical Fitness: Insights from a Preclinical Model
Loading...
Identifiers
Publication date
Authors
Santos Lozano, Alejandro
Plaza Florido, Abel
Carrera Bastos, Pedro
Pérez Prieto, Inmaculada
Hernández Belmonte, Alejandro
Advisors
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
SDG
Metrics
Abstract
Cardiorespiratory fitness (CRF) and muscle strength are associated with cancer risk/ mortality in adults. However, there is yet no evidence for pediatric tumors. This study investigated the association of CRF and muscle strength with several tumor-related phenotypes in an aggressive childhood malignancy, high-risk neuroblastoma (HR-NB).
Besides the association of CRF with clinical severity of the tumor, distinct novel tumor proteomic signatures associated with CRF and muscle strength were identified, highlighting potential mechanisms linking physical fitness with childhood cancer biology.
Description
UNESCO Subjects
Keywords
Bibliographic reference
Santos-Lozano, A., Plaza-Florido, A., Carrera-Bastos, P., Pérez-Prieto, I., Hernández-Belmonte, A., Kamalinejad, F., Gálvez, B. G., López, J. A., Lumbreras, J., Rincón-Castanedo, C., Martín-Ruiz, A., Fleck, S. J., López-Soto, A., Yanguas-Casás, N., Pinós, T., Lucia, A., & Fiuza-Luces, C. (2026). Tumor signatures of physical fitness: Insights from a preclinical model. Medicine & Science in Sports & Exercise, 58(1), 35-46. https://doi.org/10.1249/MSS.0000000000003836