Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy

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dc.contributor.authorHirsch, June C.
dc.contributor.authorAgassandian, Christopher
dc.contributor.authorMerchán-Pérez, Ángel
dc.contributor.authorBen-Ari, Yézéquiel
dc.contributor.authorDeFelipe, Javier
dc.contributor.authorEsclapez, Monique
dc.contributor.authorBernard, Christopher
dc.date.accessioned2016-11-25T19:10:26Z
dc.date.available2016-11-25T19:10:26Z
dc.date.issued1999
dc.description.abstractBecause GABA (gamma-aminobutyric acid) receptor-mediated inhibition controls the excitability of principal neurons in the brain, deficits in GABAergic inhibition have long been favored to explain seizures. In an experimental model of temporal lobe epilepsy, we have identified a deficit of inhibition in presynaptic GABAergic terminals characterized by decreased GABA quantal activity associated with reduced synaptic vesicle density. This decrease in vesicle number primarily seems to affect the reserve pool, rather than the docked or the readily releasable pool.spa
dc.description.filiationUEMspa
dc.description.impact7.157 SJR (1999) Q1, 6/97 Neuroscience (miscellaneous)spa
dc.description.sponsorshipSin financiaciónspa
dc.identifier.citationHirsch, J. C., Agassandian, C., Merchan-Perez, A., Ben-Ari, Y., Defelipe, J., Esclapez, M., y Bernard, C. (1999). Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy. Nature neuroscience, 2(6), 499-500.spa
dc.identifier.doi10.1038/9142
dc.identifier.issn10976256
dc.identifier.urihttp://hdl.handle.net/11268/6003
dc.language.isoengspa
dc.peerreviewedSispa
dc.rights.accessRightsrestricted accessspa
dc.subject.uemNeurocienciasspa
dc.subject.uemEpilepsiaspa
dc.subject.unescoNeurologíaspa
dc.subject.unescoEnfermedad del sistema nerviosospa
dc.titleDeficit of quantal release of GABA in experimental models of temporal lobe epilepsyspa
dc.typejournal articlespa
dspace.entity.typePublication

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