QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain
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Soler García, Aleix
Gamell, Anna
Santiago, Begoña
Monsonís, Manuel
Cobo Vázquez, Elvira
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Abstract
In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.
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Soler-García, A., Gamell, A., Santiago, B., Monsonís, M., Cobo-Vázquez, E., Bustillo-Alonso, M., Tagarro, A., Pérez-Gorricho, B., Espiau, M., Piqueras, A. I., Korta-Murua, J. J., Rodríguez-Molino, P., Lobato, Z., Pérez-Porcuna, T., Tebruegge, M., Noguera-Julián, A., & QFT-Plus Study Group of the Spanish Pediatric TB Research Network (2021). QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain. The Pediatric Infectious Disease Journal, 40(9), e348–e351. https://doi.org/10.1097/INF.0000000000003173