Exerkine GPLD1 bridges liver and brain

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dc.contributor.authorPlaza Florido, Abel
dc.contributor.authorCarrera Bastos, Pedro
dc.contributor.authorLucía Mulas, Alejandro
dc.date.accessioned2026-07-17T15:54:02Z
dc.date.available2026-07-17T15:54:02Z
dc.date.issued2026
dc.description.abstractA recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer’s-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.en
dc.description.filiationUEMspa
dc.description.impact37.0 Q1 JCR 2025
dc.description.impact15.978 Q1 SJR 2025
dc.description.impactNo data IDR 2024
dc.description.sponsorshipSin financiaciónes
dc.identifier.citationPlaza-Florido, A., Carrera-Bastos, P., & Lucia, A. (2026). Exerkine GPLD1 bridges liver and brain. Cell Metabolism, 38(5), 841-843. https://doi.org/10.1016/j.cmet.2026.04.002
dc.identifier.doi10.1016/J.CMET.2026.04.002
dc.identifier.issn1550-4131
dc.identifier.issn1932-7420
dc.identifier.urihttps://hdl.handle.net/11268/17282
dc.language.isoeng
dc.peerreviewedSi
dc.relation.publisherversionhttps://doi.org/10.1016/J.CMET.2026.04.002
dc.rights.accessRightsembargoed access
dc.subject.otherCiencias del Deporte
dc.subject.otherEjercicio físico
dc.subject.otherFosfolipasa D
dc.subject.otherEnvejecimiento
dc.subject.sdgGoal 3: Ensure healthy lives and promote well-being for all at all ages
dc.subject.sdgGoal 9: Build resilient infrastructure, promote sustainable industrialization and foster innovation
dc.subject.sdgGoal 10: Reduce inequality within and among countries
dc.subject.unescoCiencias médicas
dc.subject.unescoNutrición
dc.subject.unescoFisiología humana
dc.titleExerkine GPLD1 bridges liver and brainen
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
relation.isAuthorOfPublicationd3691359-d7bd-4a12-b84e-338e28c81f9f
relation.isAuthorOfPublication.latestForDiscoveryd3691359-d7bd-4a12-b84e-338e28c81f9f

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