Exerkine GPLD1 bridges liver and brain

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URI: https://hdl.handle.net/11268/17282
DOI: 10.1016/J.CMET.2026.04.002

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2026

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Plaza Florido, Abel
Carrera Bastos, Pedro

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SDG

goal-3
goal-9
goal-10

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Abstract

A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer’s-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain resilience.

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Ciencias médicas
Nutrición
Fisiología humana

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Bibliographic reference

Plaza-Florido, A., Carrera-Bastos, P., & Lucia, A. (2026). Exerkine GPLD1 bridges liver and brain. Cell Metabolism, 38(5), 841-843. https://doi.org/10.1016/j.cmet.2026.04.002
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https://doi.org/10.1016/J.CMET.2026.04.002

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journal article

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Área de Ciencias de la Salud