Mostrar el registro sencillo del ítem
dc.contributor.author | López, José Ignacio | |
dc.contributor.author | Pulido, Rafael | |
dc.contributor.author | Cortés, Jesús M. | |
dc.contributor.author | Angulo Cuesta, Javier | |
dc.contributor.author | Lawrie, Charles H. | |
dc.date.accessioned | 2018-11-06T11:30:15Z | |
dc.date.available | 2018-11-06T11:30:15Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | López, J. I., Pulido, R., Cortés, J. M., Angulo, J. C., & Lawrie, C. H. (2018). Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy. Pathology-Research and Practice, 214(8), 1110-1114. http://dx.doi.org/10.1016/j.prp.2018.06.003 | spa |
dc.identifier.issn | 0344-0338 | |
dc.identifier.issn | 1618-0631 | |
dc.identifier.uri | http://hdl.handle.net/11268/7547 | |
dc.description.abstract | Intratumor heterogeneity (ITH) detection remains a challenge in modern oncology because it can have a direct impact on the success of new therapies. Anti-PD-1/PD-L1 immunotherapy is an emerging treatment modality that is showing great promise for clear cell renal cell carcinoma (CCRCC) patients with advanced disease. Patient selection for such therapy relies upon the immunohistochemical detection of PD-1/PD-L1, however the degree of ITH for these markers among tumor cells and/or inflammatory mononuclear infiltrates remains unknown. Therefore, we analyzed PD-L1 (SP-142) expression in the tumor inflammatory cells of 22 CCRCC cases with the aim to define the pattern of PD-L1 expression, and to compare the reliability of current tumor sampling protocols (RS) with a multisite tumor sampling strategy (MSTS). While the RS protocol identified 5/22 (22.7%) of cases that were positive for PD-L1 expression, MSTS identified 10/22 (45.45%) of cases. This suggests that RS may miss a proportion of CCRCC patients that might benefit from immunotherapy. In addition, MSTS demonstrated that positive and negative regions of PD-L1 expression are very variable within each tumor. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy | spa |
dc.type | article | spa |
dc.description.impact | 1.794 JCR (2018) Q3, 45/76 Pathology | spa |
dc.description.impact | 0.604 SJR (2018) Q2, 86/210; Q3, 214/299 Cell Biology | spa |
dc.description.impact | No data IDR 2018 | spa |
dc.identifier.doi | 10.1016/j.prp.2018.06.003 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Riñones | spa |
dc.subject.uem | Cáncer | spa |
dc.subject.uem | Células cancerosas | spa |
dc.subject.unesco | Cáncer | spa |
dc.subject.unesco | Célula | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |