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dc.contributor.author | Gómez Doblas, J. J. | |
dc.contributor.author | López-Garrido, Miguel Antonio | |
dc.contributor.author | Becerra Muñoz, Víctor Manuel | |
dc.contributor.author | Orellana Figueroa, Hugo Nelson | |
dc.contributor.author | Carro Hevia, Amelia | |
dc.contributor.author | García de la Villa, Bernardo | |
dc.contributor.author | Cornide, L. | |
dc.contributor.author | Martínez Sellés Oliveria Soares, Manuel | |
dc.date.accessioned | 2018-08-13T12:24:47Z | |
dc.date.available | 2018-08-13T12:24:47Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Gómez-Doblas, J. J., López-Garrido, M. A., Becerra-Muñoz, V. M., Orellana-Figueroa, H. N., Hevia, A. C., de la Villa, B. G., ... & Martínez-Sellés, M. (2018). Significant mitral regurgitation worsens the prognosis and favors the decision of conservative treatment in octogenarians with severe symptomatic aortic stenosis. European Journal of Internal Medicine, 55, 40-46. https://doi.org/10.1016/j.ejim.2018.05.018 | spa |
dc.identifier.issn | 0953-6205 | |
dc.identifier.uri | http://hdl.handle.net/11268/7372 | |
dc.description.abstract | Introduction: The coexistence of significant mitral regurgitation (MR) and severe aortic stenosis is prevalent, has a prognostic impact and makes treatment in the elderly population a complex issue. The aim of this study is to determine the prevalence of significant MR among a population of octogenarians and its influence on treatment and prognosis. Methods: We used the data from PEGASO (Pronóstico de la Estenosis Grave Aórtica Sintomática del Octogenario), a prospective registry that consecutively included 928 patients aged ≥80 years with severe symptomatic aortic stenosis. Results: The prevalence of significant MR was 8.5% (79 patients) and independently associated with the decision to treat conservatively (odds ratio = 2.28, 95% confidence interval: 1.31–3.95, p = 0.003). The group of patients with significant MR had higher overall mortality at 12 months follow-up (51.9% vs 25%, p < 0.001), which remained on division into subgroups based on the presence of comorbidities (Charlson<5: 49.2% vs 21.9%, p < 0.001; and Charlson ≥5: 62.5% vs 41.7%, p = 0.07). Within the group of patients in whom conservative treatment was performed, those with significant MR had higher mortality at one year (62.7% vs 35%, p < 0.001). MR was a significant independent predictor of overall mortality at 12-month follow-up (hazard ratio = 1.87, 95% confidence interval: 1.09–3.18, p = 0.022). Conclusions: Significant MR has a high prevalence and worsens the prognosis of octogenarian patients with severe symptomatic aortic stenosis, especially in patients with conservative treatment, independently of the existence of comorbidities. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Significant mitral regurgitation worsens the prognosis and favors the decision of conservative treatment in octogenarians with severe symptomatic aortic stenosis | spa |
dc.type | article | spa |
dc.description.impact | 3.660 JCR (2018) Q1, 27/160 Medicine, General & Internal | spa |
dc.description.impact | 1.076 SJR (2018) Q1, 33/141 Internal Medicine | spa |
dc.description.impact | No data IDR 2018 | spa |
dc.identifier.doi | 10.1016/j.ejim.2018.05.018 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Estenosis aórtica | spa |
dc.subject.uem | Ancianos | spa |
dc.subject.unesco | Enfermedad cardiovascular | spa |
dc.subject.unesco | Anciano | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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