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dc.contributor.author | Goycochea Valdivia, Walter Alfredo | |
dc.contributor.author | Baquero Artigao, Fernando | |
dc.contributor.author | Rosal, Teresa del | |
dc.contributor.author | Frick, Marie Antoinette | |
dc.contributor.author | Rojo, Pablo | |
dc.contributor.author | Echeverría, María Juncal | |
dc.contributor.author | Noguera Julián, Antoni | |
dc.contributor.author | Bringué, Xavier | |
dc.contributor.author | Saavedra Lozano, Jesús | |
dc.contributor.author | Vives Oñós, Isabel | |
dc.contributor.author | Moliner Calderón, Elisenda | |
dc.contributor.author | Cilleruelo Ortega, María José | |
dc.contributor.author | Cuadrado, Irene | |
dc.contributor.author | Colino, Elena | |
dc.contributor.author | Castells, Laura | |
dc.contributor.author | Tagarro García, Alfredo | |
dc.contributor.author | Vilas, Javier | |
dc.contributor.author | Soler Palacín, Pere | |
dc.contributor.author | Blázquez Gamero, Daniel | |
dc.date.accessioned | 2018-04-05T12:05:32Z | |
dc.date.available | 2018-04-05T12:05:32Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Goycochea-Valdivia, W. A., Baquero-Artigao, F., del Rosal, T., Frick, M. A., Rojo, P., Echeverría, M. J., ... & Moliner, E. (2017). Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up. Clinical Infectious Diseases, 64(10), 1335-1342. DOI:10.1093/cid/cix105 | spa |
dc.identifier.issn | 1058-4838 | |
dc.identifier.uri | http://hdl.handle.net/11268/7180 | |
dc.description.abstract | BACKGROUND: DNA detection of human cytomegalovirus (hCMV) in cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) is a marker of central nervous system (CNS) involvement in congenital hCMV infection (cCMV), but its prognostic value is unknown. METHODS: A multicenter, retrospective study was performed using the Spanish Congenital Cytomegalovirus Infection Database (REDICCMV; http://www.cmvcongenito.es). Newborns with cCMV and a lumbar puncture performed were included and classified according to their hCMV-PCR in CSF result (positive/negative). Clinical characteristics, neuroimaging abnormalities, plasma viral load, and audiological and neurological outcomes of both groups were compared. RESULTS: A total of 136 neonates were included in the study: 21 (15.4%) with positive CSF hCMV-PCR and 115 (84.6%) with negative results. Seventeen patients (81%) in the positive group were symptomatic at birth compared with 52.2% of infants in the negative group (odds ratio [OR], 3.86; 95% confidence interval [CI], 1.28-14.1; P = .01). Only 4 asymptomatic newborns (6.8%) had a positive CSF hCMV-PCR. There were no differences between groups regarding the rate of microcephaly, neuroimaging abnormalities, neurological sequelae at 6 months of age, or plasma viral load. Sensorineural hearing loss (SNHL) at birth was associated with a positive CSF hCMV-PCR result (OR, 3.49; 95% CI, 1.08-11.27; P = .04), although no association was found at 6 months of age. CONCLUSIONS: A positive hCMV-PCR result in CSF is associated with symptomatic cCMV and SNHL at birth. However, no differences in neuroimaging studies, plasma viral load, or outcomes at 6 months were found. These results suggest that hCMV-PCR in CSF may not be a useful prognostic marker in cCMV. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up | spa |
dc.type | article | spa |
dc.description.impact | 9.117 JCR (2017) Q1, 11/155 Immunology, 3/88 Infectious Diseases, 11/125 Microbiology | spa |
dc.identifier.doi | 1537-6591 | |
dc.identifier.doi | 10.1093/cid/cix105 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | ADN | spa |
dc.subject.uem | Líquido cefalorraquídeo | spa |
dc.subject.uem | Lactantes | spa |
dc.subject.unesco | Gen | spa |
dc.subject.unesco | Primera infancia | spa |
dc.subject.unesco | Enfermedad del sistema nervioso | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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