Abstract:
We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL),
Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in
bisphosphonate-related osteonecrosis of the jaw (BRONJ). A case-control study in which Group 1 consisted of 41 patients with BRONJ due to bisphosphonates,
and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were
analyzed by an ELISA assay. The OPG/RANKL ratio was also calculated. We determined if the mean serum
values differed among the different stages of BRONJ. Serum levels of RANKL were lower in Group 1 than in Group 2 (p =0.01), and serum levels of OPG
were higher in patients with BRONJ than in the controls (p =0.006). The ratio of RANKL/OPG was greater in the
controls than in Group 1 (p >0.01). There were no significant differences in the serum levels of RANKL and OPG
among the different stages of osteonecrosis (p >0.05). Serum levels of RANKL and OPG, and the RANKL/OPG ratio were not valuable biomarkers for
determining the severity of oral lesions in patients with BRONJ.