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dc.contributor.author | Sanchís-Gomar, Fabián | |
dc.contributor.author | López Ramón, Marta | |
dc.contributor.author | Alis, Rafael | |
dc.contributor.author | Garatachea, Nuria | |
dc.contributor.author | Pareja Galeano, Helios | |
dc.contributor.author | Santos-Lozano, Alejandro | |
dc.contributor.author | Catalán, Pilar | |
dc.contributor.author | Sansoni, Verónica | |
dc.contributor.author | Perego, Silvia | |
dc.contributor.author | Lombardi, Giovanni | |
dc.contributor.author | Löllgen, Herbert | |
dc.contributor.author | Bueno, Héctor | |
dc.contributor.author | Serrano-Ostáriz, Enrique | |
dc.contributor.author | Lucía Mulas, Alejandro | |
dc.date.accessioned | 2016-09-20T11:39:20Z | |
dc.date.available | 2016-09-20T11:39:20Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Sanchis-Gomar, F., López-Ramón, M., Alis, R., Garatachea, N., Pareja-Galeano, H., Santos-Lozano, A., ... & Lucía, A. (2016). No evidence of adverse cardiac remodeling in former elite endurance athletes. International Journal of Cardiology, 222, 171-177. DOI: 10.1016/j.ijcard.2016.07.197 | spa |
dc.identifier.issn | 01675273 | |
dc.identifier.uri | http://hdl.handle.net/11268/5785 | |
dc.description.abstract | The impact of high exercise loads on a previously healthy heart remains controversial. We examined the consequences of decades of strenuous endurance exercise at the highest competition level on heart dimensions and volumes as well as on serum biomarkers of cardiac fibrosis/remodeling. We compared echocardiographic measurements and serum biomarkers of cardiac fibrosis/remodeling [troponin I, galectin-3, matrix metallopeptidase-2 and -9, N-terminal pro-brain natriuretic peptide, carboxy-terminal propeptide of type I procollagen, and soluble suppressor of tumorigenicity-2 (sST-2)/interleukin(IL)-1R4] in 53 male athletes [11 former professional ('elite') and 42 amateur-level ('sub-elite') cyclists or runners, aged 40-70years] and 18 aged-matched controls. A subset of 15 subjects (5 controls, 3 sub-elite and 7 elite athletes) also underwent cardiac magnetic resonance imaging (cMRI). Elite and sub-elite athletes had greater echocardiography-determined left ventricular myocardial mass indexed to body surface area than controls (113±22, 115.2±23.1 and 94.8±21g/m2, respectively, p=0.008 for group effect), with similar results for left (50.5±4.4, 48.2±4.3 and 46.4±5.2mm, p=0.008) and right (38.6±3.8, 41.1±5.5 and 34.7±4.3mm, p<0.001) ventricular end-diastolic diameter, and cMRI-determined left atrial volume indexed to body surface area (62.7±8.1, 56.4±16.0 and 39.0±14.1ml/m2, p=0.026). Two athletes showed a non-coronary pattern of small, fibrotic left ventricular patches detected by late gadolinium enhancement. No group effect was noted for biomarkers. Regardless of their competition level at a younger age, veteran endurance athletes showed an overall healthy, non-pathological pattern of cardiac remodeling. Nonetheless, the physiopathology of the ventricular fibrotic patches detected warrants further investigation. | spa |
dc.description.sponsorship | PI12/00914 | spa |
dc.language.iso | eng | spa |
dc.title | No evidence of adverse cardiac remodeling in former elite endurance athletes | spa |
dc.type | article | spa |
dc.description.impact | 6.189 JCR (2016) Q1 16/126 Cardiac and Cardiovascular Systems | spa |
dc.description.impact | 1.603 SJR (2016) Q1, 57/375 Cardiology and Cardiovascular Medicine | spa |
dc.description.impact | No data IDR 2016 | spa |
dc.identifier.doi | 10.1016/j.ijcard.2016.07.197 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Atletismo - Aspectos fisiológicos | spa |
dc.subject.uem | Corazón | spa |
dc.subject.unesco | Atleta | spa |
dc.subject.unesco | Sistema cardiovascular | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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