Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: The role of glucocorticoids

Priego, Teresa; Ibáñez de Cáceres, Inmaculada; Martín Velasco, Ana Isabel; Villanúa, María de los Ángeles; López-Calderón, Asunción

doi:10.1111/j.1749-6632.2002.tb04612.x

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Hepatic insulin-like growth factor-I binding protein 3 gene expression in rats with endotoxic shock: The role of glucocorticoids

Priego, Teresa; Ibáñez de Cáceres, Inmaculada; Martín Velasco, Ana Isabel; Villanúa, María de los Ángeles; López-Calderón, Asunción

Use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11268/5712

Fecha: 2002

Materia UNESCO: Fisiología humana

Tipo: conferenceObject

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Resumen:

The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP) - 3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.

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