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dc.contributor.author | He, Zi-Hong | |
dc.contributor.author | Hu, Yang | |
dc.contributor.author | Feng, Lianshi | |
dc.contributor.author | Bao, Dapeng | |
dc.contributor.author | Xi, Yi | |
dc.contributor.author | Wen, Li | |
dc.contributor.author | Lucía Mulas, Alejandro | |
dc.date.accessioned | 2016-07-22T15:39:58Z | |
dc.date.available | 2016-07-22T15:39:58Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | He, Z., Hu, Y., Feng, L., Bao, D., Xi, Y., Wen, L., & Lucia, A. (2007). Relationship between TFAM gene polymorphisms and endurance capacity in response to training. International journal of sports medicine, 28(12), 1059-1064. | spa |
dc.identifier.issn | 01724622 | |
dc.identifier.issn | 14393964 | |
dc.identifier.uri | http://hdl.handle.net/11268/5453 | |
dc.description.abstract | The aim of this study was to explore whether polymorphisms in mitochondrial transcription factor A ( TFAM) gene are associated with endurance capacity in a pretraining state (baseline) and/or in response to a supervised 18-wk endurance training (changes) in 102 young Chinese males (nonathletes). Phenotypes measured were running economy (RE) and V.O↓2max. Genomic DNA was extracted from white blood cells and the genotypes were analyzed by PCR-RFLP in single nucleotide polymorphisms (SNP) rs1937, rs2306604 and rs1049432. Genotype distributions were in Hardy-Weinberg equilibrium at three loci (p > 0.05). When the three polymorphisms were considered together, three haplotypes were estimated, i.e., G (rs1937)-A (rs2306604)-G (rs1049432) (49 %), G (rs1937)-G (rs2306604)-G (rs1049432) (33 %) and C (rs1937)-G (rs2306604)-T (rs1049432) (18 %). SNPrs1937 and rs1049432 achieved near complete linkage disequilibrium (LD) (D' = 1 and r↑2 = 0.903). We found no significant differences in baseline levels of V.O↓2max and RE between TFAM genotypes or haplotypes. Similarly, we found no differences for the training-induced changes of both variables. It was concluded that the three polymorphisms in TFAM gene rs1937, rs2306604 and rs1049432 do not predict endurance capacity/trainability, at least in Chinese males. | spa |
dc.description.sponsorship | Sin financiación | spa |
dc.language.iso | eng | spa |
dc.title | Relationship between TFAM gene polymorphisms and endurance capacity in response to training | spa |
dc.type | article | spa |
dc.description.impact | 1.524 JCR (2007) Q2, 21/72 Sport sciences | spa |
dc.identifier.doi | 10.1055/s-2007-965064 | |
dc.rights.accessRights | closedAccess | spa |
dc.subject.uem | Fisiología del deporte | spa |
dc.subject.uem | Genética humana | spa |
dc.subject.unesco | Genética humana | spa |
dc.description.filiation | UEM | spa |
dc.peerreviewed | Si | spa |
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